EphB4 and EphrinB2 MAbs

EphB4 is a member of the Eph family, the largest subfamily of receptor tyrosine kinases. EphB4 is found at high levels on tumor cells and in tumor-associated blood vessels. The binding of EphB4 to its ligand, EphrinB2, has been linked with the metastatic and angiogenic potential of many cancers, and antibodies targeting EphB4 or EphrinB2 may selectively inhibit the growth and survival of tumor cells and tumor-associated blood vessels.